Having beaten Sheffield Wednesday and Accrington Stanley, Boro now face League One opposition, knowing victory would take Aitor Karanka’s men to within 90 minutes of a potential semi-final berth.
The competition has had its critics and detractors in recent years, but De Roon is a fully paid up member of the FA Cup fan club and says its history and appeal will never wane.
“It’s a nice cup,” said the midfielder. “You can feel it around the town and everyone talks about it.
“The FA Cup is really big and to be at this stage and have a chance to go further...especially because we’re at home, it’s really good.
“It’s nice to play and feel the atmosphere. It’s different. If we win this you are very close to Wembley.
“Everyone in Holland talks about the FA Cup. It’s a massive competition and hopefully we can get a good result.”
This season has seen a healthy sprinkling of the magic that the competition is famed for.
Wolves won at Liverpool, non-league duo Lincoln City and Sutton United are through to the fifth round after beating Championship opponents, and Boro’s opponents on Saturday, Oxford, claimed the scalp of Newcastle in the fourth round.
“It’ll be a tough game on Saturday because Oxford will make things difficult,” said De Roon.
“You saw in the last few round, Wolves beat Liverpool and there were other results where teams surprised Premier League teams and Championship teams because they want to show they’re at a good level.
“That’s why it’s really dangerous to underestimate who you are playing. We will prepare like we do for a Premier League game.
“There’ll be no complacency. You cannot think like that. We have to do the things we know we can do.”
Season Card Holders have until Friday at 5pm to save their seat for the tie.