He has been handed squad number 36 and played the full 90 minutes of Tuesday night's Johnstone's Paint Trophy tie with Bradford City.
He scored his penalty in the shoot-out to settle the tie but Pools lost 3-2 on spot kicks to exit the competition.
Middlesbrough-born Wyke, who scored the third goal in Boro U21s' 3-1 win at Chelsea last month, signed a three-year Boro contract in summer 2011.
Although the 19-year-old prefers to play as an out-and-out striker, he is also comfortable slotting in to midfield if required.
"He came in and trained with us and from day one he looked really good," revealed Pools boss Neale Cooper.
"He's a good size, has good feet and has shown a great attitude to training so we're sure he will be a good addition for us.
"Charlie is renowned for his finishing and we've been impressed by that, but overall he's just fitted in really well so it will be good to take a look at him in competitive action.
"I'd like to thank Middlesbrough for their help on this and hopefully the player will benefit us and but also gain from the experience."