England youth internationals striker Bradley Fewster, midfielder Bryn Morris and forward Luke Williams will jet out to Madrid today (Thursday) and spend three weeks training in the Spanish capital.
They will be joined on Monday by Boro's U-21 and U-18 squads, who have scheduled friendlies against Atletico's youth teams.
Academy manager Dave Parnaby is excited about the potential benefits of working closely with a much-decorated club.
"We are keen to build relationships with Continental clubs to expand our education," he says.
"It's not just about Atletico Madrid playing Middlesbrough, it's designed to encourage player and coach development and foster positive public relations.
"It's a great opportunity for Bradley, Bryn and Luke to sample some different technical and tactical work and their spell over there will undoubtedly benefit them as individuals and players."
See Saturday's edition of Boro's Matchday programme REDSQUARE for more details of Boro's tie-up with Atletico.