The Boro manager knows struggling teams can present just as much of a threat as promotion contenders as they scrap for their lives and he's expecting the Terriers to make life difficult for his team.
"Sometimes at this stage of the season playing teams at the bottom can be more difficult than playing teams at the top because they're desperately fighting for every point," said Mowbray.
"But if we can get the first goal in these games and put them on the back foot, they can get a feeling of déjà vu. We have to try not to give anything away cheaply and see if we can get our noses in front.
"We had a good victory against Huddersfield at home early in the season. We have to try to score the first goal and get on top, as opposed to recent away games when we've given teams a goal start and made life difficult for themselves.
"We beat Leeds and followed it up with a defeat at Palace so this time it would be great to build on the win."
Goals have been at a premium at the John Smith's Stadium this season and Huddersfield's last two home games have both finished scoreless.
"They've changed their manager recently and Mark Robins is a very god manager," said Mowbray.
"He likes to play football a certain way and yet maybe at this moment he's having to compromise a little bit to make sure his team dig their way out of the potential trouble they're in.
"We know the pitch isn't the greatest and it's not necessarily going to be a great football match. We have to go there and make sure we stay in the game.
"They've got plenty of people who can score goals in players like Alan Lee, Sean Scannel, Theo Robinson and Neil Danns.
"Hopefully our travelling supporters will see a very committed, wholehearted performance and a goal or two and three points."
Boro will make a late decision on defender Jonathan Woodgate, who has missed recent games with a calf problem.
"He's trained and we'll see if there's any reaction," said Mowbray.
Saturday's goal hero Kieron Dyer is likely to be rested, while Justin Hotye (hip) and Stuart Parnaby (hamstring) are not expected to return until after the international break, meaning Nicky Bailey is set to continue in his role as an emergency right-back.
"I had no fears Nicky could do the job," said Mowbray. "He came here as a goalscoring midfield player but every day I watch him in training and he has a very defensive instinct and he'll give wingers a hard time with his tackling and robustness.
"I'm sure that Nicky would hope he's not there too much longer though!"
Lukas Jutkiewicz (ankle) is still a few weeks away from fitness.