A draw may suffice, as the six group winners and two best runners-up go through.
Boro and United have both won their games against Villarreal and Sparta Prague, so effectively this is a showdown to decide the group winner, with United currently one goal better off.
The game is the second in four days for Paul Jenkins' side who came up just short in a league game away to the runaway league leaders Swansea on Monday night.
"They (Swansea) had stunning pace down both flanks and that's where we were caught out," Jenkins admits. "That and naive defending at times.
"But I think we're in good shape for this game and we're really looking forward to it."
Boro have been steadily improving following a difficult run, a change of shape has helped.
"All we can ask is the lads do their best and continue to learn and develop, to become better players.
"We've had many challenges this year and tonight is another one, let's meet it head on and see what we can do, we have a great opportunity here."
The game is at Leigh Sports Village and has a 7pm kick-off.