The island nation of St Vincent and Grenadines is not known for its footballing pedigree, but that is the venue for Guzan's USA team on Friday evening as they continue their World Cup qualification campaign.
The United States won 6-1 when the sides met in St Louis in November, one of six successive defeats for St Vincent and the Grenadines whose most recent game brought a one-nil home defeat against St Kitts and Nevis.
Speaking ahead of the game in the Caribbean island, Guzan commented: "There has been a lot of travelling to get here, but to represent your country at any time is special and this is another chance to help try and qualify for another World Cup.
"We're looking forward to this game, but I have been watching what has been happening back in my new home and I'm looking forward to getting back to Middlesbrough and meeting my new team mates."
One of those Guzan knows well having spent last season with Adama Traore at Villa Park, but before the air reunited, Boro's goalkeeper has two matches to play as the game against St Vincent and the Grenadines is followed up with another against Trinidad and Tobago who currently top the group.
That game is in Jacksonville, Florida, on Wednesday night, after which Guzan flies back to Teesside for the game against Crystal Palace at the Riverside.
"You get used to the travelling," he says. "Some of the lads in Boro dressing room were surprised at the scale of the journeys I have to make, when I was telling them about our campaign, but I have learned to condition myself and get through it the best I can.
"It has been a good few weeks for me personally. My new team has got off to a decent start in the Premier League. Right now my focus is on these two games ahead, then getting back to Boro and hopefully keeping up the good work."