"The players will need no motivating for this one," says Lead Coach Graeme Lee.
"To be playing at the stadium is a big enough occasion for the players anyway, then add the fact it is a derby game and they should be bouncing."
Boro come into the game on the back of a narrow defeat against Wolves at Rockliffe on Monday afternoon, with Lee commenting: "That was a game that could easily have gone either way, we were pretty happy with the first half and not so with the way we played in the second.
"Let's get it right tonight and end on a high."
Kick-off is 7pm and admission is free to all Boro Season Card holders, £3 to everyone else. Car parking is £2 on a first come, first served basis.
Players will wear black armbands and there will be a minute's silence before kick-off in respect of Ugo Ehiogu who tragically passed away this morning aged just 44.