Boro’s wining streak came to an end at Sheffield Wednesday after the home side clung on for a desperate three points.
Neil Warnock’s side showed great character after trailing 2-0 at half-time and to leave Hillsborough with a 2-1 defeat was more than harsh on a Boro side who deserved more.
The Owls relieved former Boro boss Tony Pulis of his duties the previous evening and while they started with a spring in their step, it was Boro who dominated much of the contest and were the biggest threat throughout.
The home side had fired an early warning shot wide from Josh Windass while Boro were looking for an offside flag that never came, and it was a move was that to catch the visitors out again later.
One early Boro cross was cleared away and when Duncan Watmore delivered a low ball into the box Britt Assombalonga narrowly failed to make the vital connection. Watmore also sent another ball fizzing across goal.
Marvin Johnson was a constant threat and he forced a great save from Kieren Westwood.
But the hosts opened the scoring after half-hour when Callum Paterson latched on to a through ball before stabbing the ball past Marcus Bettinelli.
The second goal came moments before half time when Barry Bannan delivered a good ball into the box and Liam Shaw converted at the far post.
Watmore had a shot blocked on the stroke of half time, and on the whistle both Sam Morsy and Bannan went in the book after an altercation.
Morsy had an immediate impact in the second half, though, when his pull-back found Watmore, who drilled the ball home to get Boro back in the game.
As Boro pressed for a leveller, Lewis Wing sent a free kick into the arms of Westwood and George Saville had one blocked by the home wall.
Bettinelli did have one save to make, but it was Boro making all the running, substitute Marcus Tavernier shooting wide after a lovely lay-off by Watmore.
Johnson was next to go close when he rattled the post and Watmore saw his follow-up effort blocked as the home side were forced into some desperate defending.
Watmore also sent a shot over the top after good work by Tavernier, while Bola had a shot deflected over the top and substitute Marcus Browne sent one narrowly wide as Boro threw the kitchen sink at the Owls to no avail.