Tony Pulis has promised to shuffle his pack once again for the Carabao Cup trip to Preston on Tuesday (7.45pm).
While the travelling squad will include 10 players who have progressed through the club’s Academy, the Boro boss will also use the opportunity to give a handful of senior players some game-time.
The first of three successive away days in the space of a week for Boro, Pulis says it's necessary to utilise the players at his disposal.
"This division has moved on in every shape and form since I was last in it ten or eleven years ago," he said.
"There’s a lot better coaches and more quality teams, and that means players playing international football.
"To ask players to come back from internationals and play an extra eight games compared to the Premier League, you’re taking a lot out of them.
"We’ll make a lot of changes [at Preston] - I want the supporters to know that. The ones who’ve been in the team will get a bit of a rest, we’ve got some tough away games coming up."
Rudy Gestede returned to action for Boro's Under-23s a week ago for the first time since sustaining an ankle injury in pre-season, and he was joined by Ashley Fletcher and Sam McQueen in the starting line-up. The trio are among a number of players Pulis could turn to on Tuesday.
"They all played really well [as the Under-23s beat West Brom 3-2] , which is fabulous, what we want," the Boro manager said.
"Rudy and Fletcher will be involved and hopefully get 90 minutes against Preston.
"People like McNair, McQueen, Batth, Fry - they are the ones who will be looking to play."